Can you overcook slow cooked beef?

Online Answer
Slow Cookers and Overcooked Meat Cooking food, including meat, in a slow cooker is safe because the direct heat from the cooker and the trapped steam — along with the lengthy cooking time — ensure that all the bacteria in the food is destroyed.
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The good new is, yes, it's technically safe to leave your slow-cooker on and go about your day — as long as you are using the appliance correctly. ... To help you out, we rounded up some great tips to help you ensure you're using your slow-cooker safely and properly.
How to perfectly cook a steak. Cooked low and slow, this method produces a steak that is tender and juicy on the inside and golden brown and crust on the outside.
According to Jack Bishop of America's Test Kitchen, using the high setting on the slow cooker has the potential to ruin a dish. "If you want a beef stew with nice big chunks of beef, a lot of times the high setting can boil the meat and it dries out and sort of falls apart," he told Consumerist.
Some can be left on for up to 24 hours, but most recommend eight to 12 hours. For exactly how many hours can food be left on warm in a slow cooker? Typically, it is safe to keep cooked food "warm" for one to four hours. The key is to make sure the temperature is in the safe zone, or 145°F or over.
I use a small 3-4 pound boneless pork roast for this recipe and I like to cook it in a slow cooker on LOW for 10-12 hours. You can cook it on HIGH for 6-8 hours, but I think the texture and flavor is better when you cook it on low. I cook this Pork Roast recipe in a 4.5 quart basic crock pot..