How did the black plague end?

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How did it end? The most popular theory of how the plague ended is through the implementation of quarantines. The uninfected would typically remain in their homes and only leave when it was necessary, while those who could afford to do so would leave the more densely populated areas and live in greater isolation..
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It was believed to start in China in 1334, spreading along trade routes and reaching Europe via Sicilian ports in the late 1340s. The plague killed an estimated 25 million people, almost a third of the continent's population. The Black Death lingered on for centuries, particularly in cities.
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The idea to develop vaccine against plague started by Alexandre Yersin in 1895 who investigated immunity against Y. pestis in small animal models in his laboratory. He evaluated heat-killed whole-cell vaccine, attenuated live strains of Y. pestis, by immunization in animals with repeated boosters (17).
Shocking vision emerged from the mouse plague in New South Wales this year and, while the threat has plateaued in some areas, numbers are reportedly on the rise in parts of Victoria, southern NSW, southern Queensland and into South Australia.