Should ribs be smoked bone up or down?

Online Answer
Place ribs bone-side down in smoker at 225 F /110 C and cook for three hours. Remove ribs from the smoker and wrap tightly in aluminum foil to form an airtight seal. Return to the smoker bone-side up and smoke for two hours..
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So to answer your question. Yes you can over cook a pork shoulder or butt, brisket, roast etc. It is possible to run the gamut and over cook or over smoke food leaving a perfectly good piece of meat totally dried out or burned.